Demi Moore Says She Lost 20 Pounds, Broke Out In Shingles From 'Intensity' Of Latest Role

Demi Moore says she “put it all on the table” for her latest role, but not without consequences.

Moore stars as a fictional A-list actor in “The Substance,” a buzzed-about body-horror flick about a new drug that allows customers to birth a younger, prettier version of themselves. Naturally, things go very much awry in the film — and apparently did in real life, too.

“To give you an idea of the intensity, my first week that I actually had off, where it was just Margaret [Qualley] working, I got shingles,” Moore told the Los Angeles Times in an expansive interview Tuesday, adding: “And I then lost, like, 20 pounds.”

Shingles is a viral infection that can occur anywhere on the body and result in a painful rash. The varicella-zoster virus, which is the same one that causes chickenpox, that’s responsible for shingles can reactivate years after initial exposure — often due to stress.

“Oh, yeah,” Qualley interjected, “I had crazy acne for a full, long-ass time.”

Qualley plays the seemingly “perfect” version of Moore’s Elisabeth Sparkle, a fading star who opts to use the fictional drug. Determined to revive her career and rise from the proverbial ashes, the film’s trailer suggests Sparkle achieves anything but.

“You have to walk away feeling that you put it all on the table,” Moore told the LA Times. “It called for it and it’s what you want to bring to it.”

Though general audiences have yet to see the film, “The Substance” premiered to rave reviews in May at the Cannes Film Festival. The purportedly razor-sharp satire of Hollywood’s impossible quest for perfection currently sits at a ripe 92% critics rating on Rotten Tomatoes.

The film is already garnering Oscar buzz for Moore, as the once-ubiquitous star — who dominated the