The Latest | Blasts, gunfire heard near Rafah crossing as it remains closed under Israeli control

Gaza’s vital Rafah crossing remained closed early Wednesday after an Israeli tank brigade seized it the day before. Associated Press journalists heard sporadic explosions and gunfire in the area overnight, including two large blasts early Wednesday.

Rafah has been a vital conduit for humanitarian aid since the start of the war and is the only place where people can enter and exit. Israel now controls all of Gaza’s border crossings for the first time since it withdrew troops and settlers from the territory nearly two decades ago.

Gaza’s Health Ministry says at least 46 patients and wounded people who had been scheduled to leave for medical treatment have been left stranded.

U.N. agencies and aid groups have ramped up humanitarian assistance in recent weeks as Israel has lifted some restrictions and opened an additional crossing in the north under pressure from the United States, its closest ally. But aid workers say the closure of Rafah, which is the only gateway for the entry of fuel for trucks and generators, could have severe repercussions.

The U.N. says northern Gaza is already in a state of “full-blown famine.”

The war in Gaza has driven around 80% of the territory's population of 2.3 million from their homes and caused vast destruction to apartments, hospitals, mosques and schools across several cities. The death toll in Gaza has soared to more than 34,500 people, according to local health officials.

The war began Oct. 7 when Hamas attacked southern Israel, killing around 1,200 people, mostly civilians, and abducting about 250 others. Israel says militants still hold around 100 hostages and the remains of more than 30 others.

Currently:

— US paused bomb shipment to Israel to signal concerns over Rafah invasion,